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APC (Q2829) polyclonal antibody（KU）

貨號: BS1017

價格：￥ 1140

貨期：現貨（1-2個工作日）

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說明書 MSDS SHIP

詳細信息檢測數據實驗指南文獻

No. :BS1017

Product Name :APC (Q2829) polyclonal antibody（KU）

Swiss-Prot :P25054

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling. APC regulates ?-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :APC (Q2829) polyclonal antibody detects endogenous levels of APC protein.

BiowMW :~ 310 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5; APC; DP2.5

Immunogen :Synthetic peptide, corresponding to the C-terminal of Human APC.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of APC (Q2829) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Prevention of Chronic Experimental Colitis Induced by Dextran Sulphate Sodium (DSS) in Mice Treated with FR91

JournalJournal Of Biomedicine And Biotechnology

ApplicationIHC

IF0

SpeciesMouse

PMID22619498
In?vitro and in?vivo cytotoxic effect of AntiGan against tumor cells

JournalExperimental and Therapeutic Medicine

ApplicationIHC

IF2.447

SpeciesMouse

PMID
Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β?catenin signaling pathway

JournalOncology Letters

ApplicationWB

IF2.311

SpeciesHuman

PMID28454408